A cancer modifier role for parathyroid hormone-related protein
نویسندگان
چکیده
منابع مشابه
Expression of parathyroid hormone-related protein and the parathyroid hormone/parathyroid hormone-related protein receptor in rat thymic epithelial cells.
Thymic epithelial cells are an important source of cytokines and other regulatory peptides which guide thymocyte proliferation and maturation. Parathyroid hormone-related protein (PTHrP), a cytokine-like peptide, has been reported to affect the proliferation of lymphocytes in vitro. The studies presented here were undertaken to test the hypotheses that PTHrP is produced locally within the thymu...
متن کاملRole of Parathyroid Hormone-Related Protein Signaling in Chronic Pancreatitis
Chronic pancreatitis (CP), a progressive inflammatory disease where acini are destroyed and replaced by fibrous tissue, increases the risk for pancreatic cancer. Risk factors include alcohol, smoking, and obesity. The effects of these risk factors are exacerbated in patients with mutations in genes that predispose to CP. The different environmental and genetic factors produce the same clinical ...
متن کاملParathyroid hormone related protein and hypercalcaemia in breast cancer.
OBJECTIVE To see whether parathyroid hormone related protein has a humoral role in breast cancer. DESIGN Plasma concentrations and tumour expression of parathyroid hormone related protein were determined (by two site immunoradiometric assay and immunohistochemistry respectively) in women with breast cancer and related to the presence of bone metastases and serum calcium concentrations. SUBJ...
متن کاملChapter 26. Parathyroid Hormone-Related Protein
19. Brown EM, MacLeod RJ 2001 Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81:239-297. 20. Chang W, Chen TH, Pratt S, Shoback D 2000 Amino acids in the second and third intracellular loops of the parathyroid Ca2+sensing receptor mediate efficient coupling to phospholipase C. J Biol Chem 27519955-19963. 21. Pearce SH, Williamson C, Kifor 0, Bai M, Coulthard MG, ...
متن کاملParathyroid hormone-related protein in teleost fish.
A brief description is given of the discovery of PTHrP and the roles of the peptide in mammalian physiology. Next, the occurrence of PTHrP in the earliest vertebrates, sharks, skates and fishes, is reviewed and the calciotropic functions of PTHrP are addressed more specifically in fishes. Parathyroid hormone-related protein (PTHrP) is a hypercalcemic hormone in teleostean fishes, but also has p...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2000
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1203916